Phenotypes associated with this allele

• Allele Symbol: Pithd1^em1Osb
• Allele Name: endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
• Allele ID: MGI:6416148
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pithd1^em1Osb/Pithd1^em1Osb	involves: C57BL/6 * DBA/2	MGI:6416162

Genotype
MGI:6416162

hm1

• Allelic Composition: Pithd1^em1Osb/Pithd1^em1Osb
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

teratozoospermia ( J:285040 )

♂ • significant reduction in the number of sperm with normal morphology and increase in the frequency of sperm with multiple heads

multi-headed sperm ( J:285040 )

♂ • increase in the frequency of sperm with multiple heads

asthenozoospermia ( J:285040 )

♂ • decrease in sperm velocity after 2h incubation

impaired fertilization ( J:285040 )

♂ • in-vitro sperm fails to fertilize eggs under either the cumulus-intact or cumulus-free conditions but fertilization does take place under the zona pellucida condition

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:285040 )

N • no abnormalities were detected in the function or development of cortical thymic epithelial cells

cellular

teratozoospermia ( J:285040 )

♂ • significant reduction in the number of sperm with normal morphology and increase in the frequency of sperm with multiple heads

multi-headed sperm ( J:285040 )

♂ • increase in the frequency of sperm with multiple heads

asthenozoospermia ( J:285040 )

♂ • decrease in sperm velocity after 2h incubation