About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pithd1tm1Ohi
targeted mutation 1, Izumi Ohigashi
MGI:6416147
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pithd1tm1Ohi/Pithd1tm1Ohi involves: C57BL/6N MGI:6416161


Genotype
MGI:6416161
hm1
Allelic
Composition		 Pithd1tm1Ohi/Pithd1tm1Ohi
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pithd1tm1Ohi mutation (0 available); any Pithd1 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:285040 )
• females are fertile
• testis and epididymis weights are similar to controls
teratozoospermia ( J:285040 )
• significant reduction in the number of sperm with normal morphology and increase in the frequency of sperm with multiple heads
multi-headed sperm ( J:285040 )
• increase in the frequency of sperm with multiple heads
asthenozoospermia ( J:285040 )
• decrease in sperm velocity after 2h incubation
abnormal testis physiology ( J:285040 )
• decrease in proteasome activity in testicular cells
male infertility ( J:285040 )
• when mated to wild-type C57BL/6 females plug formation is observed but no pregnancies are detected
impaired fertilization ( J:285040 )
• in-vitro sperm fails to fertilize eggs under either the cumulus-intact or cumulus-free conditions but fertilization does take place under the zona pellucida condition

endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:285040 )
• no abnormalities were detected in the function or development of cortical thymic epithelial cells
abnormal testis physiology ( J:285040 )
• decrease in proteasome activity in testicular cells

cellular
teratozoospermia ( J:285040 )
• significant reduction in the number of sperm with normal morphology and increase in the frequency of sperm with multiple heads
multi-headed sperm ( J:285040 )
• increase in the frequency of sperm with multiple heads
asthenozoospermia ( J:285040 )
• decrease in sperm velocity after 2h incubation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory