Phenotypes associated with this allele

• Allele Symbol: Eif2b5^tm2.1Sidr
• Allele Name: targeted mutation 2.1, Carmela Sidrauski
• Allele ID: MGI:6416109
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Eif2b5^tm2.1Sidr/Eif2b5^tm2.1Sidr	B6(Cg)-Eif2b5^tm2.1Sidr	MGI:6416117

Genotype
MGI:6416117

hm1

• Allelic Composition: Eif2b5^tm2.1Sidr/Eif2b5^tm2.1Sidr
• Genetic Background: B6(Cg)-Eif2b5^tm2.1Sidr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:278928 )

N • normal lifespan

nervous system

abnormal nervous system physiology ( J:278928 )

• mice exhibit very mild phenotypes compared to Eif2b5^tm1.1Sidr homozygotes

• marker analysis indicates that the integrated stress response is induced in the central nervous system

• treatment with a small molecule Eif2b activator, 2BAct, abolishes the integrated stress response