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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Eif2b5tm2.1Sidr
targeted mutation 2.1, Carmela Sidrauski
MGI:6416109
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Eif2b5tm2.1Sidr/Eif2b5tm2.1Sidr B6(Cg)-Eif2b5tm2.1Sidr MGI:6416117


Genotype
MGI:6416117
hm1
Allelic
Composition		 Eif2b5tm2.1Sidr/Eif2b5tm2.1Sidr
Genetic
Background		 B6(Cg)-Eif2b5tm2.1Sidr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2b5tm2.1Sidr mutation (0 available); any Eif2b5 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:278928 )
N
• normal lifespan

nervous system
abnormal nervous system physiology ( J:278928 )
• mice exhibit very mild phenotypes compared to Eif2b5tm1.1Sidr homozygotes
• marker analysis indicates that the integrated stress response is induced in the central nervous system
• treatment with a small molecule Eif2b activator, 2BAct, abolishes the integrated stress response




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory