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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sec24bem1(IMPC)Tcp
endonuclease-mediated mutation 1, The Centre for Phenogenomics
MGI:6414557
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sec24bem1(IMPC)Tcp/Sec24bem1(IMPC)Tcp C57BL/6NCrl-Sec24bem1(IMPC)Tcp/Tcp MGI:7415063
ht2
 		Sec24bem1(IMPC)Tcp/Sec24b+ C57BL/6NCrl-Sec24bem1(IMPC)Tcp/Tcp MGI:7415062


Genotype
MGI:7415063
hm1
Allelic
Composition		 Sec24bem1(IMPC)Tcp/Sec24bem1(IMPC)Tcp
Genetic
Background		 C57BL/6NCrl-Sec24bem1(IMPC)Tcp/Tcp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sec24bem1(IMPC)Tcp mutation (2 available); any Sec24b mutation (68 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial

embryo

growth/size/body
abnormal head shape ( J:211773 )
IMPC - TCP
abnormal embryo size ( J:211773 )
IMPC - TCP

limbs/digits/tail

mortality/aging

nervous system
exencephaly ( J:211773 )
IMPC - TCP




Genotype
MGI:7415062
ht2
Allelic
Composition		 Sec24bem1(IMPC)Tcp/Sec24b+
Genetic
Background		 C57BL/6NCrl-Sec24bem1(IMPC)Tcp/Tcp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sec24bem1(IMPC)Tcp mutation (2 available); any Sec24b mutation (68 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
enlarged spleen ( J:211773 )
IMPC - TCP

hematopoietic system
enlarged spleen ( J:211773 )
IMPC - TCP

immune system
enlarged spleen ( J:211773 )
IMPC - TCP

vision/eye




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory