Phenotypes associated with this allele

• Allele Symbol: Usp13^em1Nmw
• Allele Name: endonuclease-mediated mutation 1, Nathaniel M Weathington
• Allele ID: MGI:6406217
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Usp13^em1Nmw/Usp13^em1Nmw	B6.Cg-Usp13^em1Nmw	MGI:6414810

Genotype
MGI:6414810

hm1

• Allelic Composition: Usp13^em1Nmw/Usp13^em1Nmw
• Genetic Background: B6.Cg-Usp13^em1Nmw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased interleukin-1 beta secretion ( J:285981 )

• in the bronchoalveolar fluid of mice exposed to intratracheal administration of LPS or Pseudomonas aeruginosa (strain PA103)

• however, lentiviral expression of Sigirr reverses induced-lung inflammation

increased interleukin-6 secretion ( J:285981 )

• in the bronchoalveolar fluid of mice exposed to intratracheal administration of LPS or Pseudomonas aeruginosa (strain PA103)

increased tumor necrosis factor secretion ( J:285981 )

• in the bronchoalveolar fluid of mice exposed to intratracheal administration of LPS or Pseudomonas aeruginosa (strain PA103)

• however, lentiviral expression of Sigirr reverses induced-lung inflammation

lung inflammation ( J:285981 )

• mice exposed to intratracheal administration of LPS or Pseudomonas aeruginosa (strain PA103) exhibit increased lung infiltration (particularly with neutrophils) and inflammation injury compared with wild-type mice

• however, lentiviral expression of Sigirr reverses induced-lung inflammation

increased susceptibility to bacterial infection ( J:285981 )

• mice exposed to intratracheal administration of LPS or Pseudomonas aeruginosa (strain PA103) exhibit increased lung infiltration (particularly with neutrophils), inflammation injury, and bronchoalveolar fluid levels of TNFalpha, IL1beta, and IL6 release in compared with wild-type mice

• however, lentiviral expression of Sigirr reverses induced-lung inflammation

respiratory system

lung inflammation ( J:285981 )

• mice exposed to intratracheal administration of LPS or Pseudomonas aeruginosa (strain PA103) exhibit increased lung infiltration (particularly with neutrophils) and inflammation injury compared with wild-type mice

• however, lentiviral expression of Sigirr reverses induced-lung inflammation