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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ezhipem1Marg
endonuclease-mediated mutation 1, Raphael Margueron
MGI:6404408
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ezhipem1Marg/Ezhipem1Marg involves: C57BL/6N MGI:6404451
ot2
 		Ezhipem1Marg/Y involves: C57BL/6N MGI:6404452


Genotype
MGI:6404451
hm1
Allelic
Composition		 Ezhipem1Marg/Ezhipem1Marg
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ezhipem1Marg mutation (0 available); any Ezhip mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased primordial ovarian follicle number ( J:281161 )
• older females (16 weeks) show a reduction in primordial follicle number and total follicle number indicating a progressive, age related, exhaustion of primordial follicle reserve
• however, no differences are seen in the number of primordial, primary, and secondary/antral follicles of pre-pubertal females
small ovary ( J:281161 )
• ovaries appear smaller
• however, uterine horns appear normal
decreased ovary weight ( J:281161 )
• ovary weight is reduced by about 30%
early reproductive senescence ( J:281161 )
• total number of pups obtained from females decrease each month as females age
reduced female fertility ( J:281161 )
• females give birth to only one litter over a period of 20 weeks compared to 3 litters for wild-type females, with fewer pups than in wild-type
decreased litter size ( J:281161 )
• females give birth to an average of 3 to 4 pups per litter compared to 8 pups per litter for wild-type

mortality/aging
early reproductive senescence ( J:281161 )
• total number of pups obtained from females decrease each month as females age

endocrine/exocrine glands
decreased primordial ovarian follicle number ( J:281161 )
• older females (16 weeks) show a reduction in primordial follicle number and total follicle number indicating a progressive, age related, exhaustion of primordial follicle reserve
• however, no differences are seen in the number of primordial, primary, and secondary/antral follicles of pre-pubertal females
small ovary ( J:281161 )
• ovaries appear smaller
• however, uterine horns appear normal
decreased ovary weight ( J:281161 )
• ovary weight is reduced by about 30%




Genotype
MGI:6404452
ot2
Allelic
Composition		 Ezhipem1Marg/Y
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ezhipem1Marg mutation (0 available); any Ezhip mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:281161 )
N
• males are fertile, sizes of germ cell subpopulations are unaffected, and although spermatozoa show slightly less progressive motility and are a bit more static, motility is not substantially affected




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory