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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mexistm1.1Pton
targeted mutation 1.1, Peter Tontonoz
MGI:6403491
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mexistm1.1Pton/Mexistm1.1Pton involves: C57BL/6 MGI:6403498


Genotype
MGI:6403498
hm1
Allelic
Composition
Mexistm1.1Pton/Mexistm1.1Pton
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mexistm1.1Pton mutation (0 available); any Mexis mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• increased number of peritoneal macrophage-derived foam cells
• decrease in ApoA-I-dependent efflux capacity in peritoneal macrophages
• cholesterol uptake

hematopoietic system
• increased number of peritoneal macrophage-derived foam cells

homeostasis/metabolism
• decrease in ApoA-I-dependent efflux capacity in peritoneal macrophages
• cholesterol uptake
• elevated cholesterol content in peritoneal macrophages when fed Western diet
• normal plasma cholesterol and triglyceride levels when fed Western or chow diet
• elevated cholesterol content in peritoneal macrophages when fed Western diet
• circulating cholesterol level

immune system
• increased number of peritoneal macrophage-derived foam cells





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory