Phenotypes associated with this allele

• Allele Symbol: Arhgef7^tm1Dprk
• Allele Name: targeted mutation 1, Dongeun Park
• Allele ID: MGI:6402582
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arhgef7^tm1Dprk/Arhgef7^tm1Dprk	involves: 129S4/SvJae * C57BL/6J	MGI:6402583

Genotype
MGI:6402583

hm1

• Allelic Composition: Arhgef7^tm1Dprk/Arhgef7^tm1Dprk
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:284300 )

• mice are resorbed at E10

embryo

abnormal embryo turning ( J:284300 )

• impaired

embryonic growth retardation ( J:284300 )

• between E8.5 and E9.5

decreased embryo size ( J:284300 )

• at E9.5

incomplete rostral neuropore closure ( J:284300 )

• incomplete closure from the hindbrain to forebrain

abnormal allantois morphology ( J:284300 )

• failure of allantois-chorion fusion

abnormal chorion morphology ( J:284300 )

• failure of allantois-chorion fusion

cellular

decreased fibroblast chemotaxis ( J:284300 )

• mouse embryonic fibroblasts exhibit defects in cell spreading, and PDGF-induced ruffle formation and chemotaxis compared with wild-type cells

increased fibroblast cell migration ( J:284300 )

• mouse embryonic fibroblasts exhibit larger focal adhesions and increased random cell motility compared with wild-type cells

• increased wound closure in mouse embryonic fibroblasts

growth/size/body

embryonic growth retardation ( J:284300 )

• between E8.5 and E9.5

decreased embryo size ( J:284300 )

• at E9.5

nervous system

incomplete rostral neuropore closure ( J:284300 )

• incomplete closure from the hindbrain to forebrain