Phenotypes associated with this allele

• Allele Symbol: Aida^tm1.1Scli
• Allele Name: targeted mutation 1.1, Sheng-Cai Lin
• Allele ID: MGI:6401842
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aida^tm1.1Scli/Aida^tm1.1Scli	involves: C57BL/6 * FVB/N	MGI:6401847

Genotype
MGI:6401847

hm1

• Allelic Composition: Aida^tm1.1Scli/Aida^tm1.1Scli
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased white adipose tissue amount ( J:262001 )

• 1.6-2.4x increase in gonadal white adipose tissue-to-body weight ratio in 4-months-old normal chow fed mice

• 1.4-1.8x increase in inguinal white adipose tissue-to-body weight ratio in 4-months-old normal chow fed mice

• 1.7-2.9x heavier gonadal white adipose tissue fat pads after 6 weeks on high-fat diet

• 1.8-2.6x heavier inguinal white adipose tissue fat pads after 6 weeks on high-fat diet

increased white fat cell size ( J:262001 )

• in gonadal and inguinal white adipose tissue after 6 weeks on high-fat diet

increased gonadal fat pad weight ( J:262001 )

• 1.6-2.4x increase in gonadal white adipose tissue-to-body weight ratio in 4-months-old normal chow fed mice

• 1.7-2.9x heavier gonadal white adipose tissue fat pads after 6 weeks on high-fat diet

increased inguinal fat pad weight ( J:262001 )

• 1.4-1.8x increase in inguinal white adipose tissue-to-body weight ratio in 4-months-old normal chow fed mice

• 1.8-2.6x heavier inguinal white adipose tissue fat pads after 6 weeks on high-fat diet

behavior/neurological

behavior/neurological phenotype ( J:262001 )

N • normal food intake in fasted mice refed high-fat diet for 1h

digestive/alimentary system

abnormal enterocyte morphology ( J:262001 )

• increased fat droplet number and size when fed high-fat diet

abnormal enterocyte physiology ( J:262001 )

• faster triglyceride accumulation after olive oil gavage

growth/size/body

obese ( J:262001 )

• progressively higher body weight on normal chow from age 8 weeks

• 2x weight gain after 6 weeks on normal chow in thermoneutral conditions

increased susceptibility to diet-induced obesity ( J:262001 )

• 1.4-1.5x higher body weight after 6 weeks on high-fat diet

increased liver weight ( J:262001 )

• 1.8-1.9x increase after 6 weeks on high-fat diet

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:262001 )

N • normal energy expenditure after short-term high fat diet

N • normal fatty acid uptake by adipose tissue, muscle, liver and serum after intraperitoneal injection of oleic acid

increased susceptibility to diet-induced obesity ( J:262001 )

• 1.4-1.5x higher body weight after 6 weeks on high-fat diet

hyperglycemia ( J:262001 )

• after 6 weeks on high-fat diet

increased circulating insulin level ( J:262001 )

• after 6 weeks on high-fat diet

increased respiratory quotient ( J:262001 )

• after short-term high fat diet

increased liver glycogen level ( J:262001 )

• after 6 weeks on high-fat diet

insulin resistance ( J:262001 )

• when subjected to oral glucose tolerance test (OGTT) after 6 weeks on high-fat diet

abnormal lipid homeostasis ( J:262001 )

• increased intestinal uptake of triolein after triolein gavage

• reduced fecal lipid content after 3 days on high-fat diet

increased triglyceride level ( J:262001 )

• in liver, brown adipose tissue (BAT) and small intestine after triolein gavage

• increased intestinal uptake of triolein after triolein gavage

increased circulating triglyceride level ( J:262001 )

• in fasted mice refed high-fat diet for 1h and gavaged with olive oil for 6h

• in fasted mice refed high-fat diet for 1h

• 1.8x increase in postprandial levels on normal chow in thermoneutral conditions

• increased intestinal uptake of triolein after triolein gavage

liver/biliary system

increased liver weight ( J:262001 )

• 1.8-1.9x increase after 6 weeks on high-fat diet

increased liver glycogen level ( J:262001 )

• after 6 weeks on high-fat diet

increased susceptibility to diet-induced hepatic steatosis ( J:262001 )

• 1.8-1.9x weight increase after 6 weeks on high-fat diet