Phenotypes associated with this allele

• Allele Symbol: Phpt1^tm1.1Eys
• Allele Name: targeted mutation 1.1, Edward Y Skolnik
• Allele ID: MGI:6401823
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Phpt1^tm1.1Eys/Phpt1^tm1.1Eys	involves: C57BL/6J * FVB/N	MGI:6401833

Genotype
MGI:6401833

hm1

• Allelic Composition: Phpt1^tm1.1Eys/Phpt1^tm1.1Eys
• Genetic Background: involves: C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

decreased insulin secretion ( J:262099 )

• impaired glucose-stimulated insulin release in isolated islets cultured under low glucose conditions

homeostasis/metabolism

decreased insulin secretion ( J:262099 )

• impaired glucose-stimulated insulin release in isolated islets cultured under low glucose conditions

decreased circulating glucose level ( J:262099 )

• significant reduction in newborn pups

• normalizes by age P2-P3

decreased circulating insulin level ( J:262099 )

• in adult mice

increased circulating insulin level ( J:262099 )

• significant increase in newborn pups

impaired glucose tolerance ( J:262099 )

• in adult mice