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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ss18l1em2Zqi
endonuclease-mediated mutation 2, Zilong Qiu
MGI:6401517
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ss18l1em2Zqi/Ss18l1em2Zqi involves: C57BL/6 MGI:6401521


Genotype
MGI:6401521
hm1
Allelic
Composition		 Ss18l1em2Zqi/Ss18l1em2Zqi
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ss18l1em2Zqi mutation (0 available); any Ss18l1 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired coordination ( J:278840 )
• mice show more foot slips in beam walking
• however, mice show no defects in open field and rotarod tests

hematopoietic system
increased microglial cell activation ( J:278840 )
• mice exhibit activated microglia in the lumbar spinal cord and cerebral motor cortex at 6 months of age

immune system
increased microglial cell activation ( J:278840 )
• mice exhibit activated microglia in the lumbar spinal cord and cerebral motor cortex at 6 months of age

nervous system
increased microglial cell activation ( J:278840 )
• mice exhibit activated microglia in the lumbar spinal cord and cerebral motor cortex at 6 months of age

cellular
increased microglial cell activation ( J:278840 )
• mice exhibit activated microglia in the lumbar spinal cord and cerebral motor cortex at 6 months of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory