Phenotypes associated with this allele

• Allele Symbol: Nlgn1^em1Taku
• Allele Name: endonuclease-mediated mutation 1, Toru Takumi
• Allele ID: MGI:6400993
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nlgn1^em1Taku/Nlgn1^em1Taku	involves: C57BL/6J	MGI:6400998
ht2	Nlgn1^em1Taku/Nlgn1^+	involves: C57BL/6J	MGI:6400995

Genotype
MGI:6400998

hm1

• Allelic Composition: Nlgn1^em1Taku/Nlgn1^em1Taku
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:247060 )

N • mice show no differences in general locomotor activity, repetitive behavior, or anxiety-like behavior are seen, and show normal social behavior in the three-chamber social interaction test and the caged social interaction tests and normal ultrasonic vocalization

impaired spatial learning ( J:247060 )

• during the training phase of the Morris water maze test, mice show a mild but a significant delay of learning both in distance traveled and latency to reach goal

abnormal spatial reference memory ( J:247060 )

• in the probe trial of the Morris water maze test, mice show no difference between the time in target and opposite, and target and adjacent left quadrant indicating a modest impairment of spatial memory

decreased aggression towards mice ( J:247060 )

• in the tube test for social dominance, mice show a lower winning rate and more often retreat from wild-type mice

nervous system

nervous system phenotype ( J:247060 )

N • hippocampal neurons show normal spine numbers

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:247060

Genotype
MGI:6400995

ht2

• Allelic Composition: Nlgn1^em1Taku/Nlgn1⁺
• Genetic Background: involves: C57BL/6J

behavior/neurological

behavior/neurological phenotype ( J:247060 )

N • no differences in olfactory habituation/dishabituation and novel object recognition test are seen and mice show normal vocalization, no differences in repetitive behavior with regards to grooming and marble burying test, no differences in general locomotor activity, anxiety-like behavior in the elevated plus-maze, and acoustic startle response

abnormal spatial reference memory ( J:247060 )

• in the probe trail of the Morris water maze test, mice spend less time in the target quadrant than wild-type mice and mice do not exhibit a difference between time in the target and adjacent quadrants, indicating impaired spatial memory

decreased aggression towards mice ( J:247060 )

• in the tube test for social dominance, heterozygotes more often retreat from wild-type mice

abnormal social investigation ( J:247060 )

• social preference index in the three-chamber test is lower than in wild-type mice

• in the caged social interaction test, mice show reduced interaction time with a stranger mouse, suggesting impaired social interaction

• however, mice show similar social behavior regarding time in chamber and time spent sniffing the stranger mouse versus inanimate object as wild-type mice in the three-chamber social interaction test

nervous system

nervous system phenotype ( J:247060 )

N • hippocampal neurons show normal spine numbers

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:247060