Analysis Tools
immune system
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• mice show increased plasma cell generation in induced autoimmune models
• IgG1+ plasma cells show reduced Ig variable gene VH1 and joining (J) gene JH1 usage but increased VH5, VH14, and JH4 usage
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• 6 weeks after induction of autoimmunity with bm12 splenocytes, mice show a 2-fold increase in the number of IgG1+ germinal center B cells and only a minimal increase in IgG1+ memory B cells
• aged mice (25 weeks) show an increase in the number of IgG1+ germinal center B cells
• mice show enhanced numbers of NP-specific IgG1+ germinal center B cells
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• 6 weeks after induction of autoimmunity with bm12 splenocytes, mice show an almost 6-fold increase in IgG1+ plasma cells in the spleen and bone marrow
• in the apoptotic thymocyte-induced autoimmune model, mice show an increase in IgG1+ plasma cells in the spleen and bone marrow
• aged mice (25 weeks) show an increase in IgG1+ plasma cells in the spleen and bone marrow
• mice show enhanced numbers of NP-specific IgG1+ plasma cells
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• 4-hydroxy-3-nitrophenylacetyl (NP)-specific IgG1 antibody responses are almost 2-fold higher and 3-fold higher during antigen recall responses
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• 4-hydroxy-3-nitrophenylacetyl (NP)-specific IgG1 antibody responses are almost 2-fold higher and 3-fold higher during antigen recall responses indicating enhanced antibody production in humoral responses upon vaccination
• mice show enhanced numbers of NP-specific IgG1+ germinal center B and plasma cells
• however, affinity maturation is not affected
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• mice adoptively transferred with bm12 splenocytes to induce lupus autoimmune disease show increased levels of IgG1 subclass anti-SmithD antibodies
• in an apoptotic thymocyte-induced autoimmune model in which mice are immunized with apoptotic thymocytes, an increase in IgG1 autoantibody production is seen
• however, IgM and IgG2b autoantibody levels are not different in the autoimmune-induced models and no differences in natural antibodies are seen under normal conditions
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• mice adoptively transferred with bm12 splenocytes to induce lupus autoimmune disease show increased levels of IgG1 subclass anti-nuclear antibodies
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• mice adoptively transferred with bm12 splenocytes to induce lupus autoimmune disease show increased levels of IgG1 subclass dsDNA antibodies
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hematopoietic system
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• mice show increased plasma cell generation in induced autoimmune models
• IgG1+ plasma cells show reduced Ig variable gene VH1 and joining (J) gene JH1 usage but increased VH5, VH14, and JH4 usage
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• 6 weeks after induction of autoimmunity with bm12 splenocytes, mice show a 2-fold increase in the number of IgG1+ germinal center B cells and only a minimal increase in IgG1+ memory B cells
• aged mice (25 weeks) show an increase in the number of IgG1+ germinal center B cells
• mice show enhanced numbers of NP-specific IgG1+ germinal center B cells
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• 6 weeks after induction of autoimmunity with bm12 splenocytes, mice show an almost 6-fold increase in IgG1+ plasma cells in the spleen and bone marrow
• in the apoptotic thymocyte-induced autoimmune model, mice show an increase in IgG1+ plasma cells in the spleen and bone marrow
• aged mice (25 weeks) show an increase in IgG1+ plasma cells in the spleen and bone marrow
• mice show enhanced numbers of NP-specific IgG1+ plasma cells
|
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• 4-hydroxy-3-nitrophenylacetyl (NP)-specific IgG1 antibody responses are almost 2-fold higher and 3-fold higher during antigen recall responses
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