Phenotypes associated with this allele

• Allele Symbol: Hdnr^em1Bbr
• Allele Name: endonuclease-mediated mutation 1, Benoit G Bruneau
• Allele ID: MGI:6400426
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hdnr^em1Bbr/Hdnr^em1Bbr	C57BL/6J-Hdnr^em1Bbr	MGI:6400483

Genotype
MGI:6400483

hm1

• Allelic Composition: Hdnr^em1Bbr/Hdnr^em1Bbr
• Genetic Background: C57BL/6J-Hdnr^em1Bbr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased heart left ventricle weight ( J:284183 )

• reduced left ventricle relative to body weight

• however, left ventricle weight following trans-aortic constriction is not increased more than in wild-type mice

increased cardiac muscle contractility ( J:284183 )

• under normal conditions or following trans-aortic constriction

muscle

increased cardiac muscle contractility ( J:284183 )

• under normal conditions or following trans-aortic constriction

respiratory system

abnormal lung weight ( J:284183 )

• following trans-aortic constriction, mice exhibit reduced lung hypertrophy compared with wild-type mice