All Phenotypes Ehd2<tm1.1Cbm> MGI Mouse

• increased beige and white coloring of brown adipose tissue compared with wild-type mice

• white adipocytes exhibit reduced caveolae number, size, and diameter compared with heterozygous cells

• under normal and glucose depletion conditions

increased white fat cell size ( J:285350 )

increased gonadal fat pad weight ( J:285350 )

• epigonadal

increased inguinal fat pad weight ( J:285350 )

• periinguinal

• brown and white adipocytes exhibit increased number of caveolae detaching from the plasma membrane compared with heterozygous cells

• however, the total number of caveolae in brown adipocytes is normal

• however, adipocytes exhibit normal glucose-stimulated lipid uptake and starvation-induced lipid release

• however, adipocytes exhibit normal glucose-stimulated lipid uptake and starvation-induced lipid release

abnormal fibroblast physiology ( J:285350 )

• embryonic fibroblasts exhibit increased caveolar mobility, lipid accumulation and adipocyte differentiation compared with control mice

• however, expression of the protein lacking the N-terminus, the EH-domain or both rescues lipid accumulation

homeostasis/metabolism phenotype ( J:285350 )

N	• mice exhibit normal plasma levels of adiponectin, leptin, and insulin

• slightly

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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