All Phenotypes Sf3b4<em1Mce> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sf3b4^em1Mce
endonuclease-mediated mutation 1, Tokyo Medical and Dental University
MGI:6393980

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sf3b4^em1Mce/Sf3b4^em1Mce	C57BL/6J-Sf3b4^em1Mce	MGI:6393987
ht2	Sf3b4^em1Mce/Sf3b4⁺	C57BL/6J-Sf3b4^em1Mce	MGI:6393988

Allelic Composition	Sf3b4^em1Mce/Sf3b4^em1Mce
Genetic Background	C57BL/6J-Sf3b4^em1Mce

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sf3b4^em1Mce mutation (0 available); any Sf3b4 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:285287 )

• mice die between late blastocyst and early implantation

Allelic Composition	Sf3b4^em1Mce/Sf3b4⁺
Genetic Background	C57BL/6J-Sf3b4^em1Mce

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sf3b4^em1Mce mutation (0 available); any Sf3b4 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal neurocranium morphology ( J:285287 )

• flat at P0 with somewhat flattened frontal, parietal, squamosal, and interparietal bones

• however, bones exhibit normal thickness

abnormal parietal bone morphology ( J:285287 )

• somewhat flattened with shortened distance between the apical edge of the left and right parietal bones

increased rib number ( J:285287 )

• ectopic ribs on the seventh cervical vertebra

thoracic vertebral transformation ( J:285287 )

• T1 to T2

• however, T13 retains is identity

cervical vertebral transformation ( J:285287 )

• ectopic ribs on the seventh cervical vertebra

decreased lumbar vertebrae number ( J:285287 )

• L6 is transformed to S1

lumbar vertebral transformation ( J:285287 )

• L6 is transformed to S1

nervous system

decreased neuronal precursor proliferation ( J:285287 )

• of PHH3positive cell in the forebrain

decreased forebrain size ( J:285287 )

growth/size/body

flat head ( J:285287 )

decreased body size ( J:285287 )

• up to 8weeks of age

craniofacial

abnormal neurocranium morphology ( J:285287 )

• flat at P0 with somewhat flattened frontal, parietal, squamosal, and interparietal bones

• however, bones exhibit normal thickness

abnormal parietal bone morphology ( J:285287 )

• somewhat flattened with shortened distance between the apical edge of the left and right parietal bones

flat head ( J:285287 )

cellular

decreased neuronal precursor proliferation ( J:285287 )

• of PHH3positive cell in the forebrain

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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