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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sf3b4em1Mce
endonuclease-mediated mutation 1, Tokyo Medical and Dental University
MGI:6393980
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sf3b4em1Mce/Sf3b4em1Mce C57BL/6J-Sf3b4em1Mce MGI:6393987
ht2
 		Sf3b4em1Mce/Sf3b4+ C57BL/6J-Sf3b4em1Mce MGI:6393988


Genotype
MGI:6393987
hm1
Allelic
Composition		 Sf3b4em1Mce/Sf3b4em1Mce
Genetic
Background		 C57BL/6J-Sf3b4em1Mce
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sf3b4em1Mce mutation (0 available); any Sf3b4 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality before implantation, complete penetrance ( J:285287 )
• mice die between late blastocyst and early implantation




Genotype
MGI:6393988
ht2
Allelic
Composition		 Sf3b4em1Mce/Sf3b4+
Genetic
Background		 C57BL/6J-Sf3b4em1Mce
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sf3b4em1Mce mutation (0 available); any Sf3b4 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal neurocranium morphology ( J:285287 )
• flat at P0 with somewhat flattened frontal, parietal, squamosal, and interparietal bones
• however, bones exhibit normal thickness
abnormal parietal bone morphology ( J:285287 )
• somewhat flattened with shortened distance between the apical edge of the left and right parietal bones
increased rib number ( J:285287 )
• ectopic ribs on the seventh cervical vertebra
thoracic vertebral transformation ( J:285287 )
• T1 to T2
• however, T13 retains is identity
cervical vertebral transformation ( J:285287 )
• ectopic ribs on the seventh cervical vertebra
decreased lumbar vertebrae number ( J:285287 )
• L6 is transformed to S1
lumbar vertebral transformation ( J:285287 )
• L6 is transformed to S1

nervous system
decreased neuronal precursor proliferation ( J:285287 )
• of PHH3positive cell in the forebrain

growth/size/body
flat head ( J:285287 )
decreased body size ( J:285287 )
• up to 8weeks of age

craniofacial
abnormal neurocranium morphology ( J:285287 )
• flat at P0 with somewhat flattened frontal, parietal, squamosal, and interparietal bones
• however, bones exhibit normal thickness
abnormal parietal bone morphology ( J:285287 )
• somewhat flattened with shortened distance between the apical edge of the left and right parietal bones

cellular
decreased neuronal precursor proliferation ( J:285287 )
• of PHH3positive cell in the forebrain




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory