All Phenotypes Klhl3<tm1.1Slin> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klhl3^tm1.1Slin/Klhl3^tm1.1Slin	Not Specified	MGI:6393415
ht2	Klhl3^tm1.1Slin/Klhl3⁺	Not Specified	MGI:6393411

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

increased systemic arterial systolic blood pressure ( J:284284 )

homeostasis/metabolism

acidemia ( J:284284 )

decreased circulating bicarbonate level ( J:284284 )

increased circulating aldosterone level ( J:284284 )

hyperkalemia ( J:284284 )

increased circulating chloride level ( J:284284 )

decreased urine potassium level ( J:284284 )

• mice show decreased fractional excretion of potassium

metabolic acidosis ( J:284284 )

• hyperchloremic metabolic acidosis

decreased renin activity ( J:284284 )

• secondary hyporeninemia

abnormal physiological response to xenobiotic ( J:284284 )

• mice show a blunted diuretic response to treatment with furosemide (NKCC2 inhibitor), showing decreased fractional excretion of sodium, potassium and chloride

• mice show an increased diuretic response to hydrochlorothiazide (NCC inhibitor), showing increased fractional excretion of sodium, potassium and chloride

renal/urinary system

decreased urine potassium level ( J:284284 )

• mice show decreased fractional excretion of potassium

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pseudohypoaldosteronism		DOID:4479		J:284284

Allelic Composition	Klhl3^tm1.1Slin/Klhl3⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klhl3^tm1.1Slin mutation (0 available); any Klhl3 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

increased systemic arterial systolic blood pressure ( J:284284 )

renal/urinary system

decreased urine potassium level ( J:284284 )

• mice show decreased fractional excretion of potassium

homeostasis/metabolism

acidemia ( J:284284 )

decreased circulating bicarbonate level ( J:284284 )

increased circulating aldosterone level ( J:284284 )

hyperkalemia ( J:284284 )

increased circulating chloride level ( J:284284 )

decreased urine potassium level ( J:284284 )

• mice show decreased fractional excretion of potassium

metabolic acidosis ( J:284284 )

• hyperchloremic metabolic acidosis

decreased renin activity ( J:284284 )

• secondary hyporeninemia

abnormal physiological response to xenobiotic ( J:284284 )

• mice show an increased diuretic response to hydrochlorothiazide (NCC inhibitor), showing increased fractional excretion of sodium, potassium and chloride

• mice show a blunted diuretic response to treatment with furosemide (NKCC2 inhibitor), showing decreased fractional excretion of sodium, potassium and chloride

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pseudohypoaldosteronism		DOID:4479		J:284284

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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