Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fmc1em1Aitn mutation
(0 available);
any
Fmc1 mutation
(19 available)
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mortality/aging
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• mice begin to die after birth through 14 days of age
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• mice begin to die after birth through 14 days of age
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cellular
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• reduced complex I activity in the heart
• however, complex I activity in the brain is normal
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fmc1em1Aitn mutation
(0 available);
any
Fmc1 mutation
(19 available)
|
|
|
cellular
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• mice are protected from MPTP-induced motor deficits and dopaminergic neurons in the substantia nigra compared with wild-type mice
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• MPTP-treated mice fail to exhibit a decrease in complex I activity unlike wild-type mice
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nervous system
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• mice are protected from MPTP-induced motor deficits and dopaminergic neurons in the substantia nigra compared with wild-type mice
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behavior/neurological
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• mice are protected from MPTP-induced motor deficits
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homeostasis/metabolism