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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fmc1em1Aitn
endonuclease-mediated mutation 1, Ayako Isotani
MGI:6392175
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fmc1em1Aitn/Fmc1em1Aitn C57BL/6JJmsSlc-Fmc1em1Aitn MGI:6392233
ht2
 		Fmc1em1Aitn/Fmc1+ C57BL/6JJmsSlc-Fmc1em1Aitn MGI:6392234


Genotype
MGI:6392233
hm1
Allelic
Composition		 Fmc1em1Aitn/Fmc1em1Aitn
Genetic
Background		 C57BL/6JJmsSlc-Fmc1em1Aitn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fmc1em1Aitn mutation (0 available); any Fmc1 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:257586 )
• mice begin to die after birth through 14 days of age
postnatal lethality, incomplete penetrance ( J:257586 )
• mice begin to die after birth through 14 days of age

cellular
abnormal mitochondrial ATP synthesis coupled electron transport ( J:257586 )
• reduced complex I activity in the heart
• however, complex I activity in the brain is normal




Genotype
MGI:6392234
ht2
Allelic
Composition		 Fmc1em1Aitn/Fmc1+
Genetic
Background		 C57BL/6JJmsSlc-Fmc1em1Aitn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fmc1em1Aitn mutation (0 available); any Fmc1 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased susceptibility to neuronal excitotoxicity ( J:257586 )
• mice are protected from MPTP-induced motor deficits and dopaminergic neurons in the substantia nigra compared with wild-type mice
abnormal mitochondrial ATP synthesis coupled electron transport ( J:257586 )
• MPTP-treated mice fail to exhibit a decrease in complex I activity unlike wild-type mice

nervous system
decreased susceptibility to neuronal excitotoxicity ( J:257586 )
• mice are protected from MPTP-induced motor deficits and dopaminergic neurons in the substantia nigra compared with wild-type mice

behavior/neurological
impaired behavioral response to xenobiotic ( J:257586 )
• mice are protected from MPTP-induced motor deficits

homeostasis/metabolism
decreased susceptibility to neuronal excitotoxicity ( J:257586 )
• mice are protected from MPTP-induced motor deficits and dopaminergic neurons in the substantia nigra compared with wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory