Phenotypes associated with this allele

• Allele Symbol: Abcc9^em2Nich
• Allele Name: endonuclease-mediated mutation 2, Colin G Nichols
• Allele ID: MGI:6389242
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Abcc9^em2Nich/Abcc9^em2Nich	involves: C57BL/6J * CBA/J	MGI:6389243

Genotype
MGI:6389243

hm1

• Allelic Composition: Abcc9^em2Nich/Abcc9^em2Nich
• Genetic Background: involves: C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

dilated heart left ventricle ( J:281630 )

• mild left ventricular dilatation in diastole

decreased cardiac muscle contractility ( J:281630 )

• left ventricle fractional shortening is decreased

abnormal heart echocardiography feature ( J:281630 )

• echocardiography shows decreased left ventricle fractional shortening and a small, but significant, increase in left ventricular internal dimension in diastole

increased systemic arterial blood pressure ( J:281630 )

• blood pressure is increased

muscle

decreased cardiac muscle contractility ( J:281630 )

• left ventricle fractional shortening is decreased

increased muscle fatigability ( J:281630 )

• while mice perform normally in the initial trail of the inverted screen test of strength, in subsequent trials, mice show decreased performance, with mice remaining inverted a shorter time than wild-type mice indicating increased fatigability

nervous system

abnormal channel response ( J:281630 )

• inside-out patch clamp recordings from ventricular myocytes and aortic smooth muscle cells show that functional K(ATP) channels are absent

behavior/neurological

behavior/neurological phenotype ( J:281630 )

N • mice do not exhibit cognitive or behavioral defects, including no deficits in learning and memory and do not show anxiety-like behaviors