All Phenotypes Prdm12<tm1.1Ejbd> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Prdm12^tm1.1Ejbd
targeted mutation 1.1, Eric J Bellefroid
MGI:6386418

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Avil^tm2(cre)Fawa/Avil⁺ Prdm12^tm1.1Ejbd/Prdm12^tm1.1Ejbd	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N	MGI:6387033

Allelic Composition	Avil^tm2(cre)Fawa/Avil⁺ Prdm12^tm1.1Ejbd/Prdm12^tm1.1Ejbd
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Avil^tm2(cre)Fawa mutation (2 available); any Avil mutation (46 available)
Prdm12^tm1.1Ejbd mutation (0 available); any Prdm12 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased neuron apoptosis ( J:283226 )

• at E16.5 in the dorsal root ganglia

decreased sensory neuron number ( J:283226 )

• reduced neurons expressing nociception markers in the dorsal root ganglia at E15.5 and E18.5

• strongly reduced peptidergic and non-peptidergic projections in the dorsal horn

• reduced Islet1+ neurons in the dorsal root ganglia at E16.5

abnormal superior glossopharyngeal ganglion morphology ( J:283226 )

• reduced superior jugular ganglia at E14.5

small trigeminal ganglion ( J:283226 )

• at E14.5

cellular

increased neuron apoptosis ( J:283226 )

• at E16.5 in the dorsal root ganglia

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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