Phenotypes associated with this allele

• Allele Symbol: Prdm12^tm1Ejbd
• Allele Name: targeted mutation 1, Eric J Bellefroid
• Allele ID: MGI:6386384
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prdm12^tm1Ejbd/Prdm12^tm1Ejbd	involves: C57BL/6J * C57BL/6N	MGI:6387027
cx2	Prdm12^tm1Ejbd/Prdm12^tm1Ejbd Tg(Sox10-Venus)1Okn/0	involves: C57BL/6J * C57BL/6N	MGI:6387032

Genotype
MGI:6387027

hm1

• Allelic Composition: Prdm12^tm1Ejbd/Prdm12^tm1Ejbd
• Genetic Background: involves: C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:283226 )

• mice die within hours of birth

nervous system

increased neuron apoptosis ( J:283226 )

• in the dorsal root ganglia at E12.5

• however, cell proliferation is normal

decreased neuron number ( J:283226 )

• reduction in the number of small neurons in the dorsal root ganglia at E13.5 and E14.5

decreased sensory neuron number ( J:283226 )

• absent in the superior jugular ganglia at E13.5

abnormal superior glossopharyngeal ganglion morphology ( J:283226 )

• absent superior jugular ganglia at E11.5 and E14.5

• Tlx3 confirmed the absence of sensory neurons in the superior jugular ganglia at E13.5

small trigeminal ganglion ( J:283226 )

• at E11.5 and E14.5

small dorsal root ganglion ( J:283226 )

• at E14.5, but not E11.5, due to reduced neurons primarily small neurons

cellular

increased neuron apoptosis ( J:283226 )

• in the dorsal root ganglia at E12.5

• however, cell proliferation is normal

Genotype
MGI:6387032

cx2

• Allelic Composition: Prdm12^tm1Ejbd/Prdm12^tm1Ejbd; Tg(Sox10-Venus)1Okn/0
• Genetic Background: involves: C57BL/6J * C57BL/6N

nervous system

abnormal neurite morphology ( J:283226 )

• selective loss of small cutaneous sensory fibers at E13.5 and E14.5 in the dorsal root ganglia