Phenotypes associated with this allele

• Allele Symbol: Arl3^{Gt(EUCJ0159b07)1.1Hmgu}
• Allele Name: gene trap 1.1, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:6386241
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Arl3^Gt(EUCJ0159b07)1.1Hmgu/Arl3^Gt(EUCJ0159b07)1.1Hmgu Tg(Rho-icre)1Ck/0	involves: C57BL/6J * C57BL/6N * SJL	MGI:6386321
cn2	Arl3^Gt(EUCJ0159b07)1.1Hmgu/Arl3^Gt(EUCJ0159b07)1.1Hmgu Tg(Six3-cre)69Frty/0	involves: C57BL/6N * DBA/2	MGI:6386322

Genotype
MGI:6386321

cn1

• Allelic Composition: Arl3^{Gt(EUCJ0159b07)1.1Hmgu}/Arl3^{Gt(EUCJ0159b07)1.1Hmgu}; Tg(Rho-icre)1Ck/0
• Genetic Background: involves: C57BL/6J * C57BL/6N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina rod cell outer segment morphology ( J:232436 )

• slightly reduced

retina cone cell degeneration ( J:232436 )

• at 2 months

retina rod cell degeneration ( J:232436 )

• at 2 months

thin retina inner nuclear layer ( J:232436 )

• slightly

decreased total retina thickness ( J:232436 )

• progressive, at P15 and further by P50

abnormal cone electrophysiology ( J:232436 )

• begins to decline at 1 month

abnormal rod electrophysiology ( J:232436 )

• reduced a- and b-waves at 1 month

• however, readings at P15 are normal

behavior/neurological

abnormal optokinetic reflex ( J:232436 )

• extinct at 2 months

• however, optokinetic response at 1 month is normal

nervous system

abnormal retina rod cell outer segment morphology ( J:232436 )

• slightly reduced

retina cone cell degeneration ( J:232436 )

• at 2 months

retina rod cell degeneration ( J:232436 )

• at 2 months

Genotype
MGI:6386322

cn2

• Allelic Composition: Arl3^{Gt(EUCJ0159b07)1.1Hmgu}/Arl3^{Gt(EUCJ0159b07)1.1Hmgu}; Tg(Six3-cre)69Frty/0
• Genetic Background: involves: C57BL/6N * DBA/2

vision/eye

abnormal photoreceptor connecting cilium morphology ( J:232436 )

• lack of ciliogenesis

• however, ciliogenesis is rescued by adenovirus expression of the protein

short photoreceptor outer segment ( J:232436 )

• absent in the central retina with a lack of ciliogenesis

• however, the outer segment is present in the retina periphery and ciliogenesis is rescued by adenovirus expression of the protein

retina cone cell degeneration ( J:232436 )

• at P15

retina rod cell degeneration ( J:232436 )

• at P15

retina degeneration ( J:232436 )

• at 2 month with no response to light

abnormal cone electrophysiology ( J:232436 )

• reduced at P15 and further at 1 month

abnormal rod electrophysiology ( J:232436 )

• reduced at P15 and further at 1 month

behavior/neurological

abnormal optokinetic reflex ( J:232436 )

• reduced at 1 month and nearly extinguished at 2 months

nervous system

abnormal photoreceptor connecting cilium morphology ( J:232436 )

• lack of ciliogenesis

• however, ciliogenesis is rescued by adenovirus expression of the protein

short photoreceptor outer segment ( J:232436 )

• absent in the central retina with a lack of ciliogenesis

• however, the outer segment is present in the retina periphery and ciliogenesis is rescued by adenovirus expression of the protein

retina cone cell degeneration ( J:232436 )

• at P15

retina rod cell degeneration ( J:232436 )

• at P15

cellular

abnormal photoreceptor connecting cilium morphology ( J:232436 )

• lack of ciliogenesis

• however, ciliogenesis is rescued by adenovirus expression of the protein