All Phenotypes Gm30731<tm1.1Dalm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gm30731^tm1.1Dalm
targeted mutation 1.1, Daniel A Lim
MGI:6385064

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gm30731^tm1.1Dalm/Gm30731^tm1.1Dalm Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺	involves: 129S6/SvEvTac * C57BL/6NCrl	MGI:6385158
cn2	Gm30731^tm1.1Dalm/Gm30731^tm1.1Dalm Emx1^tm1(cre)Krj/Emx1⁺	involves: 129S/SvEv * 129S2/SvPas * C57BL/6	MGI:6385155
cn3	Gm30731^tm1.1Dalm/Gm30731^tm1.1Dalm Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/Ndor1⁺	involves: 129S/SvEv * C57BL/6	MGI:6385157

Allelic Composition	Gm30731^tm1.1Dalm/Gm30731^tm1.1Dalm Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gm30731^tm1.1Dalm mutation (0 available); any Gm30731 mutation (0 available)
Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze} mutation (5 available); any Gt(ROSA)26Sor mutation (944 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuronal stem cell physiology ( J:281278 )

• cell-autonomous increased neurogenesis following injection of a cre-expressing adenovirus into lateral ventricles at E13.5

Allelic Composition	Gm30731^tm1.1Dalm/Gm30731^tm1.1Dalm Emx1^tm1(cre)Krj/Emx1⁺
Genetic Background	involves: 129S/SvEv * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1^tm1(cre)Krj mutation (2 available); any Emx1 mutation (34 available)
Gm30731^tm1.1Dalm mutation (0 available); any Gm30731 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebral cortex morphology ( J:281278 )

• altered postnatal cortical lamination

abnormal neocortex morphology ( J:281278 )

increased neuron number ( J:281278 )

• of CTIP2+neurons in the cortical plate at E13.5

abnormal neuronal stem cell physiology ( J:281278 )

• reduced proliferation of ventricular zone cells at E13.5

• fewer neurons born at E15.5 and P14 in the cortex with reduced BrdU+;CUX1+ cells in the upper layers

Allelic Composition	Gm30731^tm1.1Dalm/Gm30731^tm1.1Dalm Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/Ndor1⁺
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gm30731^tm1.1Dalm mutation (0 available); any Gm30731 mutation (0 available)
Ndor1^{Tg(UBC-cre/ERT2)1Ejb} mutation (6 available); any Ndor1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuronal stem cell physiology ( J:281278 )

• increased neurogenesis of ventricular-subventricular zone neural stem cell cultures treated with tamoxifen with 6-fold more neurons

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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