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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(CAG-COX7A2L)#Sinos
transgene insertion, Satoshi Inoue
MGI:6384937
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Cox7a2lGt(OST241316)Lex/Cox7a2lGt(OST241316)Lex
Tg(CAG-COX7A2L)#Sinos/0 		involves: 129S5/SvEvBrd * C57BL/6 MGI:6384941
tg2
 		Tg(CAG-COX7A2L)#Sinos/0 involves: C57BL/6 MGI:6384940


Genotype
MGI:6384941
cx1
Allelic
Composition		 Cox7a2lGt(OST241316)Lex/Cox7a2lGt(OST241316)Lex
Tg(CAG-COX7A2L)#Sinos/0
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cox7a2lGt(OST241316)Lex mutation (1 available); any Cox7a2l mutation (60 available)
Tg(CAG-COX7A2L)#Sinos mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue
abnormal brown adipose tissue morphology ( J:215964 )
• brown adipose tissue weight is increased more than in wild-type mice but less than in single Cox7a1lGt(OST241316)Lex homozygotes

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:215964 )
N
• mice exhibit normal running ability in the forced treadmill test




Genotype
MGI:6384940
tg2
Allelic
Composition		 Tg(CAG-COX7A2L)#Sinos/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased carbon dioxide production ( J:215964 )
• mice show an increase in CO2 production (VCO2) in the steady state
increased oxygen consumption ( J:215964 )
• mice show an increase in oxygen consumption (VO2) in the steady state
increased aerobic running capacity ( J:215964 )
• mice show 130% of the running capacity in the forced treadmill test
abnormal enzyme/coenzyme activity ( J:215964 )
• cytochrome c oxidase (COX) activity is enhanced in MEFs

cellular
increased fibroblast proliferation ( J:215964 )
• cell proliferation is enhanced in MEFs

adipose tissue
adipose tissue phenotype ( J:215964 )
N
• brown adipose tissue weights are similar to wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory