Phenotypes associated with this allele

• Allele Symbol: Aff4^em1(IMPC)Mbp
• Allele Name: endonuclease-mediated mutation 1, Mouse Biology Program, UC Davis
• Allele ID: MGI:6382405
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aff4^em1(IMPC)Mbp/Aff4^em1(IMPC)Mbp	C57BL/6N-Aff4^em1(IMPC)Mbp/MbpMmucd	MGI:6480382
ht2	Aff4^em1(IMPC)Mbp/Aff4^+	C57BL/6N-Aff4^em1(IMPC)Mbp/MbpMmucd	MGI:6492691

Genotype
MGI:6480382

hm1

• Allelic Composition: Aff4^em1(IMPC)Mbp/Aff4^em1(IMPC)Mbp
• Genetic Background: C57BL/6N-Aff4^em1(IMPC)Mbp/MbpMmucd

Data Sources

IMPC Data for Aff4

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:211773 )

IMPC - UCD

abnormal placenta vasculature ( J:211773 )

♀

IMPC - UCD

craniofacial

abnormal craniofacial morphology ( J:211773 )

♀

IMPC - UCD

embryo

embryonic growth retardation ( J:211773 )

IMPC - UCD

abnormal placenta morphology ( J:211773 )

♀

IMPC - UCD

abnormal placenta vasculature ( J:211773 )

♀

IMPC - UCD

growth/size/body

embryonic growth retardation ( J:211773 )

IMPC - UCD

homeostasis/metabolism

edema ( J:211773 )

♀

IMPC - UCD

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - UCD

vision/eye

microphthalmia ( J:211773 )

IMPC - UCD

anophthalmia ( J:211773 )

♀

IMPC - UCD

Genotype
MGI:6492691

ht2

• Allelic Composition: Aff4^em1(IMPC)Mbp/Aff4⁺
• Genetic Background: C57BL/6N-Aff4^em1(IMPC)Mbp/MbpMmucd

Data Sources

IMPC Data for Aff4

behavior/neurological

increased freezing behavior ( J:211773 )

♂

IMPC - UCD

increased grip strength ( J:211773 )

IMPC - UCD

growth/size/body

decreased body length ( J:211773 )

IMPC - UCD

integument

abnormal skin morphology ( J:211773 )

♂

IMPC - UCD

limbs/digits/tail

abnormal caudal vertebrae morphology ( J:211773 )

IMPC - UCD

renal/urinary system

abnormal kidney morphology ( J:211773 )

♀

IMPC - UCD

small kidney ( J:211773 )

♀

IMPC - UCD

skeleton

abnormal caudal vertebrae morphology ( J:211773 )

IMPC - UCD