Analysis Tools
adipose tissue
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• inguinal white adipose tissue (iWAT) of mice maintained at room temperature shows large clustered populations of cells with smaller multilocular lipid droplets indicative of browning of WAT deposits
• however, perigonadal white adipose tissue (pWAT) shows no differences from wild-type mice
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growth/size/body
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• mice fed a high-fat diet show lower body weight than wild-type mice on chow diet at room temperature and gain 30% less weight than controls, however no differences in food intake or activity level are seen
• iWAT and pWAT depots are approximately 30% lower in weight in mice fed a high-fat diet
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homeostasis/metabolism
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• mice fed a high-fat diet show lower body weight than wild-type mice on chow diet at room temperature and gain 30% less weight than controls, however no differences in food intake or activity level are seen
• iWAT and pWAT depots are approximately 30% lower in weight in mice fed a high-fat diet
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• mice subjected to an acute cold exposure show a smaller drop in rectal temperature than wild-type mice, showing improved thermogenic capacity
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• mice fed a standard chow diet and maintained at room temperature have 0.7 degrees Celcius higher core body temperature
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• 10% higher oxygen consumption rate (VO2) during both day and night cycles
• 70% increase in oxygen consumption rate in iWAT
• however, no alterations in oxygen consumption rate in brown adipose tissue (BAT) is seen
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• mice fed a high-fat diet have improved glucose tolerance compared to wild-type mice
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• mice fed a high-fat diet have improved insulin sensitivity compared to wild-type mice
increase in energy expenditure
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