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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adamts16em1Amc
endonuclease-mediated mutation 1, Andrew P McMahon
MGI:6377449
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Adamts16em1Amc/Adamts16em1Amc Not Specified MGI:6377453
cx2
 		Adamts16em1Amc/Adamts16em1Amc
Adamts18tm1(KOMP)Vlcg/Adamts18tm1(KOMP)Vlcg 		involves: C57BL/6NTac MGI:6377458


Genotype
MGI:6377453
hm1
Allelic
Composition		 Adamts16em1Amc/Adamts16em1Amc
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts16em1Amc mutation (1 available); any Adamts16 mutation (83 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
respiratory system phenotype ( J:280280 )
N
• no lung development abnormalities are seen




Genotype
MGI:6377458
cx2
Allelic
Composition		 Adamts16em1Amc/Adamts16em1Amc
Adamts18tm1(KOMP)Vlcg/Adamts18tm1(KOMP)Vlcg
Genetic
Background		 involves: C57BL/6NTac
Cell Lines 12442A-F3
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts16em1Amc mutation (1 available); any Adamts16 mutation (83 available)
Adamts18tm1(KOMP)Vlcg mutation (2 available); any Adamts18 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
double ureter ( J:280280 )
• 35% of mice exhibit double ureters, with 4% having bilateral double ureter
• position of secondary ureter formation varies
• kidneys with double ureters have more total epithelial length, total epithelial volume, and total tip numbers compared to single ureters in wild-type mice but to a similar level as seen in single Adam18 homozygotes
• 73% of double ureter occur in the left kidney

respiratory system
abnormal lung development ( J:280280 )
• lungs resemble the lungs of Adam18 homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory