Phenotypes associated with this allele

• Allele Symbol: Adamts16^em1Amc
• Allele Name: endonuclease-mediated mutation 1, Andrew P McMahon
• Allele ID: MGI:6377449
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adamts16^em1Amc/Adamts16^em1Amc	Not Specified	MGI:6377453
cx2	Adamts16^em1Amc/Adamts16^em1Amc Adamts18^tm1(KOMP)Vlcg/Adamts18^tm1(KOMP)Vlcg	involves: C57BL/6NTac	MGI:6377458

Genotype
MGI:6377453

hm1

• Allelic Composition: Adamts16^em1Amc/Adamts16^em1Amc
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

respiratory system phenotype ( J:280280 )

N • no lung development abnormalities are seen

Genotype
MGI:6377458

cx2

• Allelic Composition: Adamts16^em1Amc/Adamts16^em1Amc; Adamts18^{tm1(KOMP)Vlcg}/Adamts18^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac
• Cell Lines: 12442A-F3

renal/urinary system

double ureter ( J:280280 )

• 35% of mice exhibit double ureters, with 4% having bilateral double ureter

• position of secondary ureter formation varies

• kidneys with double ureters have more total epithelial length, total epithelial volume, and total tip numbers compared to single ureters in wild-type mice but to a similar level as seen in single Adam18 homozygotes

• 73% of double ureter occur in the left kidney

respiratory system

abnormal lung development ( J:280280 )

• lungs resemble the lungs of Adam18 homozygotes