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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Emc3em1Xjz
endonuclease-mediated mutation 1, Xianjun Zhu
MGI:6376213
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Emc3em1Xjz/Emc3em1Xjz
Tg(CAG-cre/Esr1*)5Amc/0 		involves: C57BL/6J * CBA MGI:6376225


Genotype
MGI:6376225
cn1
Allelic
Composition		 Emc3em1Xjz/Emc3em1Xjz
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emc3em1Xjz mutation (0 available); any Emc3 mutation (16 available)
Tg(CAG-cre/Esr1*)5Amc mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal photoreceptor outer segment morphology ( J:280458 )
• reduced Rho trafficking to the outer segment in tamoxifen-treated mice
thin retina outer nuclear layer ( J:280458 )
• at P31, but not P27, in tamoxifen-treated mice
retina degeneration ( J:280458 )
• in the outer segment of tamoxifen-treated mice

nervous system
abnormal photoreceptor outer segment morphology ( J:280458 )
• reduced Rho trafficking to the outer segment in tamoxifen-treated mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory