Phenotypes associated with this allele

• Allele Symbol: Nudt7^em1Ejj
• Allele Name: endonuclease-mediated mutation 1, Eun-Jung Jin
• Allele ID: MGI:6369729
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nudt7^em1Ejj/Nudt7^em1Ejj	involves: C57BL/6N	MGI:6369730

Genotype
MGI:6369730

hm1

• Allelic Composition: Nudt7^em1Ejj/Nudt7^em1Ejj
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

increased susceptibility to induced arthritis ( J:266261 )

• destabilization of the medial meniscus (DMM) surgery-induced mice show typical osteoarthritis characteristics, with severe cartilage degeneration, a reduction in cartilage thickness, and decrease in chondrocyte numbers

• DMM-induced mice fed a phytol enriched diet show more severely deteriorative osteoarthritis phenotypes such as increased cartilage degeneration, reduced cartilage thickness, and reduced chondrocyte numbers than wild-type mice

osteoarthritis ( J:266261 )

• DMM surgery-induced mice show typical osteoarthritis characteristics

• mice fed a phytol enriched diet show severe cartilage degeneration without DMM surgery

abnormal chondrocyte physiology ( J:266261 )

• immature murine articular chondrocytes exhibit mitochondrial dysfunction and pyruvate accumulation under phytol-enriched conditions

• immature murine articular chondrocytes show an accumulation of 2-phosphoglycerate, acetyl-CoA, and malonyl-CoA

increased chondrocyte apoptosis ( J:266261 )

• immature murine articular chondrocyte apoptosis is increased in culture under phytol-enriched conditions

decreased chondrocyte proliferation ( J:266261 )

• immature murine articular chondrocyte proliferation is decreased in culture

immune system

increased susceptibility to induced arthritis ( J:266261 )

• destabilization of the medial meniscus (DMM) surgery-induced mice show typical osteoarthritis characteristics, with severe cartilage degeneration, a reduction in cartilage thickness, and decrease in chondrocyte numbers

• DMM-induced mice fed a phytol enriched diet show more severely deteriorative osteoarthritis phenotypes such as increased cartilage degeneration, reduced cartilage thickness, and reduced chondrocyte numbers than wild-type mice

osteoarthritis ( J:266261 )

• DMM surgery-induced mice show typical osteoarthritis characteristics

• mice fed a phytol enriched diet show severe cartilage degeneration without DMM surgery

cellular

increased chondrocyte apoptosis ( J:266261 )

• immature murine articular chondrocyte apoptosis is increased in culture under phytol-enriched conditions

decreased chondrocyte proliferation ( J:266261 )

• immature murine articular chondrocyte proliferation is decreased in culture

abnormal peroxisome physiology ( J:266261 )

• immature murine articular chondrocytes exhibit peroxisome dysfunction