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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tbx6em1Fzh
endonuclease-mediated mutation 1, Feng Zhang
MGI:6368858
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tbx6em1Fzh/Tbx6em1Fzh FVB/NJ-Tbx6em1Fzh MGI:6441992
ht2
 		Tbx6em1Fzh/Tbx6+ FVB/NJ-Tbx6em1Fzh MGI:6441993
ht3
 		Tbx6em1Fzh/Tbx6em2Fzh FVB/NJ-Tbx6em1Fzh Tbx6em2Fzh MGI:6441997


Genotype
MGI:6441992
hm1
Allelic
Composition		 Tbx6em1Fzh/Tbx6em1Fzh
Genetic
Background		 FVB/NJ-Tbx6em1Fzh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx6em1Fzh mutation (0 available); any Tbx6 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:271649 )
• no homozygous mice are obtained




Genotype
MGI:6441993
ht2
Allelic
Composition		 Tbx6em1Fzh/Tbx6+
Genetic
Background		 FVB/NJ-Tbx6em1Fzh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx6em1Fzh mutation (0 available); any Tbx6 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:271649 )
N
• mice show no evidence of congenital vertebral malformations




Genotype
MGI:6441997
ht3
Allelic
Composition		 Tbx6em1Fzh/Tbx6em2Fzh
Genetic
Background		 FVB/NJ-Tbx6em1Fzh Tbx6em2Fzh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx6em1Fzh mutation (0 available); any Tbx6 mutation (19 available)
Tbx6em2Fzh mutation (0 available); any Tbx6 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal vertebrae development ( J:271649 )
• 93% of embryos and 100% of adult mice (35-445 days) exhibit congenital vertebral malformations




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory