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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cars2em1Akai
endonuclease-mediated mutation 1, Takaaki Akaike
MGI:6368616
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cars2em1Akai/Cars2em1Akai involves: C57BL/6N MGI:6368618
ht2
 		Cars2em1Akai/Cars2+ involves: C57BL/6N MGI:6368619


Genotype
MGI:6368618
hm1
Allelic
Composition		 Cars2em1Akai/Cars2em1Akai
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cars2em1Akai mutation (0 available); any Cars2 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality ( J:254717 )
• no homozygous mice are produced from hetrozygous intercrosses




Genotype
MGI:6368619
ht2
Allelic
Composition		 Cars2em1Akai/Cars2+
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cars2em1Akai mutation (0 available); any Cars2 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal mitochondrial physiology ( J:254717 )
• marked attenuation of cysteine hydrosulfide (CysSHH) production
• heterozygous mice were born normally without any apparent abnormalities in macroscopic appearence or growth profiles during 6 month after birth




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory