Phenotypes associated with this allele

• Allele Symbol: Trim40^em1Caox
• Allele Name: endonuclease-mediated mutation 1, Xuetao Cao
• Allele ID: MGI:6368568
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim40^em1Caox/Trim40^em1Caox	involves: C57BL/6J	MGI:6368571

Genotype
MGI:6368571

hm1

• Allelic Composition: Trim40^em1Caox/Trim40^em1Caox
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal fibroblast physiology ( J:255265 )

• in cultured MEF in vitro, enhanced cytoplasmic poly(I:C)-induced IFN-beta secretion

• in cultur4ed MEF in vitro, vesicular stomatitis virus replication were decreased and more resistant to infection

mortality/aging

decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:255265 )

• more resistant in survival assays upon VSV infection

• show enhanced survival ability

hematopoietic system

abnormal macrophage physiology ( J:255265 )

• in isolated peritoneal macrophages in vitro, significantly increased secretion of IFN-beta, tumor necrosis factor alpha, and IL-6 after infection by Sendai virus and vesicular stomatitis virus

immune system

abnormal immune system physiology ( J:255265 )

• when challenged with virus, IFN-beta secretion in serum was significantly increased and viral titer and replication in liver and lung were greatly decreased

abnormal macrophage physiology ( J:255265 )

• in isolated peritoneal macrophages in vitro, significantly increased secretion of IFN-beta, tumor necrosis factor alpha, and IL-6 after infection by Sendai virus and vesicular stomatitis virus

decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:255265 )

• more resistant in survival assays upon VSV infection

• show enhanced survival ability