Phenotypes associated with this allele

• Allele Symbol: Tpm2^em1Eku
• Allele Name: endonuclease-mediated mutation 1, Eri Kubo
• Allele ID: MGI:6368153
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tpm2^em1Eku/Tpm2^em1Eku	involves: C57BL/6NCr	MGI:6368155
ht2	Tpm2^em1Eku/Tpm2^+	involves: C57BL/6NCr	MGI:6368154

Genotype
MGI:6368155

hm1

• Allelic Composition: Tpm2^em1Eku/Tpm2^em1Eku
• Genetic Background: involves: C57BL/6NCr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:258198 )

• time of lethality not specified

Genotype
MGI:6368154

ht2

• Allelic Composition: Tpm2^em1Eku/Tpm2⁺
• Genetic Background: involves: C57BL/6NCr

vision/eye

abnormal lens morphology ( J:258198 )

• the anterior and equatorial-bow regions of lenses in 86-week old mice show progression of swelling, liquefaction, and fiber disruption

abnormal lens fiber morphology ( J:258198 )

• small vacuoles and slight swelling of lens fiber are seen in 16-week, but not 7-week, old mice

• lenses of 53-week old mice show disorganization of fibers and formation of vacuoles at the lens anterior surface

cataract ( J:258198 )

• 53-week old lenses show central opacity in the anterior cortex

homeostasis/metabolism

impaired wound healing ( J:258198 )

• on days 5 and 10 after needle puncture of lenses to create wounds, fibroblastic changes around the wounded area are smaller than in wild-type lenses