Phenotypes associated with this allele

• Allele Symbol: Rgcc^tm1Hrus
• Allele Name: targeted mutation 1, Horea Rus
• Allele ID: MGI:6367994
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rgcc^tm1Hrus/Rgcc^tm1Hrus	involves: 129S6/SvEvTac * C57BL/6	MGI:6368009

Genotype
MGI:6368009

hm1

• Allelic Composition: Rgcc^tm1Hrus/Rgcc^tm1Hrus
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:279555 )

• fewer than expected mice are born when breeding heterozygotes

immune system

increased T cell proliferation ( J:279555 )

• in unstimulated T cells and when stimulated by anti-CD3 and anti-CD28 antibodies

increased interleukin-2 secretion ( J:279555 )

• from T cells stimulated by anti-CD3 and anti-CD28 antibodies

• however, treatment with LY294002 reverses the phenotype

cellular

increased T cell proliferation ( J:279555 )

• in unstimulated T cells and when stimulated by anti-CD3 and anti-CD28 antibodies

hematopoietic system

increased T cell proliferation ( J:279555 )

• in unstimulated T cells and when stimulated by anti-CD3 and anti-CD28 antibodies