Phenotypes associated with this allele

• Allele Symbol: Mirc29^tm1.1Wtsi
• Allele Name: targeted mutation 1.1, Wellcome Trust Sanger Institute
• Allele ID: MGI:6367595
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mirc29^tm1.1Wtsi/Mirc29^tm1.1Wtsi	C57BL/6N-Mirc29^tm1.1Wtsi	MGI:6367620
cx2	Mirc29^tm1.1Wtsi/Mirc29^tm1.1Wtsi Mirc33^tm1.1Wtsi/Mirc33^tm1.1Wtsi	C57BL/6N-Mirc29^tm1.1Wtsi Mirc33^tm1.1Wtsi	MGI:6367622

Genotype
MGI:6367620

hm1

• Allelic Composition: Mirc29^tm1.1Wtsi/Mirc29^tm1.1Wtsi
• Genetic Background: C57BL/6N-Mirc29^tm1.1Wtsi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:267719 )

• slight decrease in body weight

• however, mice develop normally without any obvious alterations

renal/urinary system

ischuria ( J:267719 )

• old mice develop urinary retention with incomplete penetrance

cardiovascular system

cardiovascular system phenotype ( J:267719 )

N • no fibrotic accumulation in the coronary arteries is seen

Genotype
MGI:6367622

cx2

• Allelic Composition: Mirc29^tm1.1Wtsi/Mirc29^tm1.1Wtsi; Mirc33^tm1.1Wtsi/Mirc33^tm1.1Wtsi
• Genetic Background: C57BL/6N-Mirc29^tm1.1Wtsi Mirc33^tm1.1Wtsi

mortality/aging

premature death ( J:267719 )

• life span is reduced to a median of 23 days

growth/size/body

decreased body weight ( J:267719 )

• mice show reduced body weight few days after birth

postnatal growth retardation ( J:267719 )

• striking growth retardation

cardiovascular system

abnormal heart morphology ( J:267719 )

• necrotic areas with collagen accumulation are seen in hearts

homeostasis/metabolism

increased fasting circulating glucose level ( J:267719 )

• fasted mice exhibit hyperglycemia

decreased circulating glucose level ( J:267719 )

• reduction in serum glucose concentration in nonfasted mice

decreased circulating insulin level ( J:267719 )