Phenotypes associated with this allele

• Allele Symbol: Slamf9^em1Isha
• Allele Name: endonuclease-mediated mutation 1, Idit Shachar
• Allele ID: MGI:6364884
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slamf9^em1Isha/Slamf9^em1Isha	involves: C57BL/6	MGI:6364885

Genotype
MGI:6364885

hm1

• Allelic Composition: Slamf9^em1Isha/Slamf9^em1Isha
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased plasmacytoid dendritic cell number ( J:279164 )

• 1.9-fold increase in the frequency of plasmacytoid dendritic cells (pDCs) in the lymph nodes and among total live cells and in their absolute numbers

• the pDC accumulation in the lymph nodes results from both enhanced egress from the bone marrow and enhanced pDC survival

• however, the proportion of B cell and conventional dendritic cells (cDC) populations in the periphery or macrophages is mostly unchanged

• mice induced to develop experimental autoimmune encephalomyelitis show an increase in pDC frequencies in the bone marrow and lymph nodes and in the brain and spinal cord

immune system

increased plasmacytoid dendritic cell number ( J:279164 )

• 1.9-fold increase in the frequency of plasmacytoid dendritic cells (pDCs) in the lymph nodes and among total live cells and in their absolute numbers

• the pDC accumulation in the lymph nodes results from both enhanced egress from the bone marrow and enhanced pDC survival

• however, the proportion of B cell and conventional dendritic cells (cDC) populations in the periphery or macrophages is mostly unchanged

• mice induced to develop experimental autoimmune encephalomyelitis show an increase in pDC frequencies in the bone marrow and lymph nodes and in the brain and spinal cord

abnormal plasmacytoid dendritic cell physiology ( J:279164 )

• pDCs from the spleen show lower intracellular levels of IFN-alpha and TNF-alpha when stimulated with CpG ODN1585, a synthetic ligand for Toll-like receptor 9, indicating aberrant cytokine production by pDCs

• pDCs derived from EAE-induced mice express lower levels of IFN-gamma, IL-6, and TNF-alpha following CpGA stimulation

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:279164 )

• mice show a delayed onset of experimental autoimmune encephalomyelitis (EAE) and milder disease following induction with myelin oligodendrocyte glycoprotein 33-55 peptide