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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tfap2bem1Fenli
endonuclease-mediated mutation 1, Fen Li
MGI:6364882
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tfap2bem1Fenli/Tfap2bem1Fenli involves: C57BL/6 MGI:6393314


Genotype
MGI:6393314
hm1
Allelic
Composition
Tfap2bem1Fenli/Tfap2bem1Fenli
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfap2bem1Fenli mutation (0 available); any Tfap2b mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most newborns die within 3 hours after birth and all die before P1

cardiovascular system
• slight kidney congestion
• the number of ductal smooth muscle cells is decreased in the ductus arteriosus
• mice show partially delayed closure of the ductus arteriosus
• mice exhibit patent ductus arteriosus (PDA); all mice present with wide PDA at 2 hours after birth and about 42% of pups that survive longer than 6 hours and less than 24 hours show a shunt in the ductus arteriosus
• marker analysis indicates that mice exhibit alterations in functional contraction of ductal smooth muscle cells

muscle
• marker analysis indicates that mice exhibit alterations in functional contraction of ductal smooth muscle cells

renal/urinary system
• kidneys appear slightly hyperemic and edematous at birth
• slight kidney congestion
• some small cysts in kidneys
• tubular dilation is seen in the area of distal tubuli and collecting duct system

cellular
• mice show partially delayed closure of the ductus arteriosus
• mice exhibit patent ductus arteriosus (PDA); all mice present with wide PDA at 2 hours after birth and about 42% of pups that survive longer than 6 hours and less than 24 hours show a shunt in the ductus arteriosus

craniofacial
N
• mice exhibit no palatal anomalies

limbs/digits/tail
N
• mice exhibit normal digits

growth/size/body
• some small cysts in kidneys

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
patent ductus arteriosus DOID:13832 OMIM:607411
J:278067





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory