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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ehfem1Zfa
endonuclease-mediated mutation 1, Zusen Fan
MGI:6364857
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ehfem1Zfa/Ehfem1Zfa C57BL/6-Ehfem1Zfa MGI:6367578
cn2
 		Bptfem1Zfa/Bptfem1Zfa
Ehfem1Zfa/Ehfem1Zfa
Lgr5tm1(cre/ERT2)Cle/Lgr5+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:6367579


Genotype
MGI:6367578
hm1
Allelic
Composition		 Ehfem1Zfa/Ehfem1Zfa
Genetic
Background		 C57BL/6-Ehfem1Zfa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ehfem1Zfa mutation (0 available); any Ehf mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal digestive system development ( J:268724 )
• reduced intestinal stem cells with impaired organoid formation capacity
abnormal crypts of Lieberkuhn morphology ( J:268724 )
• short with fewer cells than in wild-type mice
abnormal small intestinal villus morphology ( J:268724 )
• short with fewer cells than in wild-type mice

endocrine/exocrine glands
abnormal crypts of Lieberkuhn morphology ( J:268724 )
• short with fewer cells than in wild-type mice




Genotype
MGI:6367579
cn2
Allelic
Composition		 Bptfem1Zfa/Bptfem1Zfa
Ehfem1Zfa/Ehfem1Zfa
Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bptfem1Zfa mutation (0 available); any Bptf mutation (157 available)
Ehfem1Zfa mutation (0 available); any Ehf mutation (26 available)
Lgr5tm1(cre/ERT2)Cle mutation (1 available); any Lgr5 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal digestive system development ( J:268724 )
• almost blocked organoid formation from intestinal stem cells

homeostasis/metabolism
abnormal response to radiation ( J:268724 )
• severely impaired intestinal epithelium regeneration after radiation injury compared with wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory