Phenotypes associated with this allele

• Allele Symbol: Bptf^em1Zfa
• Allele Name: endonuclease-mediated mutation 1, Zusen Fan
• Allele ID: MGI:6364856
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Bptf^em1Zfa/Bptf^em1Zfa Lgr5^tm1(cre/ERT2)Cle/Lgr5^+	involves: 129P2/OlaHsd * C57BL/6	MGI:6367576
cn2	Bptf^em1Zfa/Bptf^em1Zfa Ehf^em1Zfa/Ehf^em1Zfa Lgr5^tm1(cre/ERT2)Cle/Lgr5^+	involves: 129P2/OlaHsd * C57BL/6	MGI:6367579
cn3	A930024E05Rik^em2Zfa/A930024E05Rik^em2Zfa Bptf^em1Zfa/Bptf^em1Zfa Satb1^em1Zfa/Satb1^em1Zfa Tg(Rorc-cre)1Litt/0	involves: C57BL/6 * FVB	MGI:7311735
cn4	Bptf^em1Zfa/Bptf^em1Zfa Tg(Rorc-cre)1Litt/0	involves: C57BL/6 * FVB	MGI:7311743

Genotype
MGI:6367576

cn1

• Allelic Composition: Bptf^em1Zfa/Bptf^em1Zfa; Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal digestive system development ( J:268724 )

• reduced intestinal stem cells with impaired organoid formation capacity

Genotype
MGI:6367579

cn2

• Allelic Composition: Bptf^em1Zfa/Bptf^em1Zfa; Ehf^em1Zfa/Ehf^em1Zfa; Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

digestive/alimentary system

abnormal digestive system development ( J:268724 )

• almost blocked organoid formation from intestinal stem cells

homeostasis/metabolism

abnormal response to radiation ( J:268724 )

• severely impaired intestinal epithelium regeneration after radiation injury compared with wild-type mice

Genotype
MGI:7311735

cn3

• Allelic Composition: A930024E05Rik^em2Zfa/A930024E05Rik^em2Zfa; Bptf^em1Zfa/Bptf^em1Zfa; Satb1^em1Zfa/Satb1^em1Zfa; Tg(Rorc-cre)1Litt/0
• Genetic Background: involves: C57BL/6 * FVB

hematopoietic system

decreased common lymphocyte progenitor cell number ( J:259392 )

• reduced absolute numbers of ILC3 cells due to reduced proliferation

• however, overexpression of Zfp292 rescues ILC3 proliferation

Genotype
MGI:7311743

cn4

• Allelic Composition: Bptf^em1Zfa/Bptf^em1Zfa; Tg(Rorc-cre)1Litt/0
• Genetic Background: involves: C57BL/6 * FVB

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:259392 )

• in C. rodentium exposed mice

immune system

increased susceptibility to bacterial infection ( J:259392 )

• C. rodentium-infected mice exhibit increased colon shortening, persistent intestinal damage, and increased mortality compared with control mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:259392 )

• in C. rodentium exposed mice

hematopoietic system

decreased common lymphocyte progenitor cell number ( J:259392 )

• reduced absolute numbers of ILC3 cells due to impaired proliferation