Phenotypes associated with this allele

• Allele Symbol: Zdhhc4^em1Smoc
• Allele Name: endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• Allele ID: MGI:6363130
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zdhhc4^em1Smoc/Zdhhc4^em1Smoc	C57BL/6JSmoc-Zdhhc4^em1Smoc	MGI:6363200

Genotype
MGI:6363200

hm1

• Allelic Composition: Zdhhc4^em1Smoc/Zdhhc4^em1Smoc
• Genetic Background: C57BL/6JSmoc-Zdhhc4^em1Smoc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

impaired adaptive thermogenesis ( J:270120 )

• cold-exposed mice exhibit greater and longer temperature drop and lower plasma glucose levels compared with wild-type mice

• however, cold-posed mice exhibit normal brown adipose tissue mass and morphology

decreased circulating glucose level ( J:270120 )

• in cold-exposed mice

abnormal lipid homeostasis ( J:270120 )

• reduced fatty acid uptake in brown and white adipose tissue, heart and muscle

increased circulating free fatty acids level ( J:270120 )

• after gavage of olive oil indicating slow clearance

increased circulating triglyceride level ( J:270120 )

• after gavage of olive oil indicating slow clearance

adipose tissue

adipose tissue phenotype ( J:270120 )

N • whether fed standard chow or a high-fat diet, mice exhibit normal white adipose tissue

growth/size/body

growth/size/body region phenotype ( J:270120 )

N • whether fed standard chow or a high-fat diet, mice exhibit normal body weight