Phenotypes associated with this allele

• Allele Symbol: Zdhhc5^tm1.1Smoc
• Allele Name: targeted mutation 1.1, Shanghai Model Organisms Center
• Allele ID: MGI:6363129
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Zdhhc5^tm1.1Smoc/Zdhhc5^tm1.1Smoc Tg(Adipoq-cre)1Evdr/0	involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ	MGI:6363198

Genotype
MGI:6363198

cn1

• Allelic Composition: Zdhhc5^tm1.1Smoc/Zdhhc5^tm1.1Smoc; Tg(Adipoq-cre)1Evdr/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:270120 )

• in cold-exposed mice

abnormal lipid homeostasis ( J:270120 )

• reduced fatty acid uptake in brown and white adipose tissue

• however, uptake in heart and muscle are normal

increased circulating free fatty acids level ( J:270120 )

• after gavage of olive oil indicating slow clearance that is not as profound as in Zdhhc4^em1Smoc homozygotes

• in cold-exposed mice

increased circulating triglyceride level ( J:270120 )

• after gavage of olive oil indicating slow clearance that is not as profound as in Zdhhc4^em1Smoc homozygotes

adipose tissue

adipose tissue phenotype ( J:270120 )

N • whether fed standard chow or a high-fat diet, mice exhibit normal white adipose tissue

growth/size/body

growth/size/body region phenotype ( J:270120 )

N • whether fed standard chow or a high-fat diet, mice exhibit normal body weight