Phenotypes associated with this allele

• Allele Symbol: Mir185^em1Smoc
• Allele Name: endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• Allele ID: MGI:6363070
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir185^em1Smoc/Mir185^em1Smoc	Not Specified	MGI:6363304

Genotype
MGI:6363304

hm1

• Allelic Composition: Mir185^em1Smoc/Mir185^em1Smoc
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

growth/size/body region phenotype ( J:278853 )

N • mice have a normal body weight and body length and do not exhibit spontaneous phenotypes

cellular

enhanced osteoblast differentiation ( J:278853 )

• primary osteoblasts undergoing osteoblastic induction show increased alkaline phosphatase activity 7-14 days after induction, and increased mineralization and enhanced mineralized matrix formation after 14 and 21 days of induction, indicating increased differentiation

increased osteoblast proliferation ( J:278853 )

• primary osteoblasts derived from neonatal calvaria exhibit increased proliferative ability in CCK-8 assays

homeostasis/metabolism

increased alkaline phosphatase activity ( J:278853 )

• primary osteoblasts undergoing osteoblastic induction for 7-14 days show increased alkaline phosphatase activity

• mesenchymal stem cells show enhanced activity of alkaline phosphatase 7 days after osteoblastic induction

skeleton

enhanced osteoblast differentiation ( J:278853 )

• primary osteoblasts undergoing osteoblastic induction show increased alkaline phosphatase activity 7-14 days after induction, and increased mineralization and enhanced mineralized matrix formation after 14 and 21 days of induction, indicating increased differentiation

increased osteoblast proliferation ( J:278853 )

• primary osteoblasts derived from neonatal calvaria exhibit increased proliferative ability in CCK-8 assays

increased bone mineral density ( J:278853 )

• ovariectomized females exhibit higher bone mineral density than wild-type mice

increased bone volume ( J:278853 )

• the bone volume/total volume of femur epiphyses are less reduced in ovariectomized mutant than wild-type females

decreased susceptibility to osteoporosis ( J:278853 )

• ovariectomized females exhibit decreased osteoporosis compared to wild-type mice, showing greater trabecular thickness and trabecular bone area, less reduced trabecular bone number and bone volume/total volume of femur epiphyses, and lower trabecular spacing and trabecular pattern factor

increased bone trabecula number ( J:278853 )

• trabecular bone number of femur epiphyses are less reduced in ovariectomized mutant than wild-type females

decreased bone trabecular spacing ( J:278853 )

• ovariectomized females exhibit lower trabecular spacing

decreased trabecular bone connectivity density ( J:278853 )

• ovariectomized females exhibit lower trabecular pattern factor

increased trabecular bone thickness ( J:278853 )

• ovariectomized females exhibit greater trabecular thickness than in wild-type mice

increased bone ossification ( J:278853 )

• mesenchymal stem cells and primary ostoblasts show enhanced activity of alkaline phosphatase 7-14 days after osteoblastic induction and enhanced mineralization after induction for 21 days, indicating enhanced osteogenic function