Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-Mtg1)3Ywxu
• Allele Name: transgene insertion 3, Yawei Xu
• Allele ID: MGI:6362670
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myh6-Mtg1)3Ywxu/0	involves: C57BL/6J	MGI:6362876

Genotype
MGI:6362876

tg1

• Allelic Composition: Tg(Myh6-Mtg1)3Ywxu/0
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased myocardial fiber number ( J:271147 )

• in response to pressure overload that is not as severe as in similarly treated wild-type mice

increased heart weight ( J:271147 )

• in response to pressure overload that is not as severe as in similarly treated wild-type mice

cardiac fibrosis ( J:271147 )

• in response to pressure overload that is not as severe as in similarly treated wild-type mice

increased cardiac muscle contractility ( J:271147 )

• in response to pressure overload that is not as severe as in similarly treated wild-type mice

decreased response of heart to induced stress ( J:271147 )

• following pressure overload, mice exhibit reduced heart weight, cardiomyocyte cross-sectional area and cardiac fibrosis with improved contractile function compared with wild-type mice

respiratory system

increased lung weight ( J:271147 )

• in response to pressure overload that is not as severe as in similarly treated wild-type mice

cellular

abnormal mitochondrial ATP synthesis coupled electron transport ( J:271147 )

• reduction complex I, II and IV activity in response to pressure overload that is not as severe as in similarly treated wild-type mice

homeostasis/metabolism

decreased response of heart to induced stress ( J:271147 )

• following pressure overload, mice exhibit reduced heart weight, cardiomyocyte cross-sectional area and cardiac fibrosis with improved contractile function compared with wild-type mice

muscle

increased myocardial fiber number ( J:271147 )

• in response to pressure overload that is not as severe as in similarly treated wild-type mice

increased cardiac muscle contractility ( J:271147 )

• in response to pressure overload that is not as severe as in similarly treated wild-type mice

growth/size/body

increased heart weight ( J:271147 )

• in response to pressure overload that is not as severe as in similarly treated wild-type mice

increased lung weight ( J:271147 )

• in response to pressure overload that is not as severe as in similarly treated wild-type mice