Phenotypes associated with this allele

• Allele Symbol: Mtg1^em1Ywxu
• Allele Name: endonuclease-mediated mutation 1, Yawei Xu
• Allele ID: MGI:6362669
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mtg1^em1Ywxu/Mtg1^em1Ywxu	Not Specified	MGI:6362875

Genotype
MGI:6362875

hm1

• Allelic Composition: Mtg1^em1Ywxu/Mtg1^em1Ywxu
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased myocardial fiber number ( J:271147 )

• increased cardiomyocyte cross-sectional area more so than in wild-type mice in response to pressure overload

increased heart weight ( J:271147 )

• more so than in wild-type mice in response to pressure overload

cardiac fibrosis ( J:271147 )

• more so than in wild-type mice in response to pressure overload

increased cardiac muscle contractility ( J:271147 )

• more so than in wild-type mice in response to pressure overload

• however, the phenotype is improved when mice are treated with N-acetyl-L-cysteine

increased response of heart to induced stress ( J:271147 )

• increased cardia hypertrophy (with increased heart weight and increased cardiomyocyte cross-sectional area), cardiac fibrosis and increased lung weight more so than in wild-type mice in response to pressure overload

• however, the phenotypes are improved when mice are treated with N-acetyl-L-cysteine

cellular

abnormal mitochondrial ATP synthesis coupled electron transport ( J:271147 )

• exacerbated reduction complex I, II and IV activity in response to pressure overload

respiratory system

increased lung weight ( J:271147 )

• more so than in wild-type mice in response to pressure overload

homeostasis/metabolism

increased response of heart to induced stress ( J:271147 )

• increased cardia hypertrophy (with increased heart weight and increased cardiomyocyte cross-sectional area), cardiac fibrosis and increased lung weight more so than in wild-type mice in response to pressure overload

• however, the phenotypes are improved when mice are treated with N-acetyl-L-cysteine

muscle

increased myocardial fiber number ( J:271147 )

• increased cardiomyocyte cross-sectional area more so than in wild-type mice in response to pressure overload

increased cardiac muscle contractility ( J:271147 )

• more so than in wild-type mice in response to pressure overload

• however, the phenotype is improved when mice are treated with N-acetyl-L-cysteine

growth/size/body

increased heart weight ( J:271147 )

• more so than in wild-type mice in response to pressure overload

increased lung weight ( J:271147 )

• more so than in wild-type mice in response to pressure overload