Phenotypes associated with this allele

• Allele Symbol: Slco3a1^em1Smoc
• Allele Name: endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• Allele ID: MGI:6361972
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slco3a1^em1Smoc/Slco3a1^em1Smoc	C57BL/6J-Slco3a1^em1Smoc/Smoc	MGI:6361974

Genotype
MGI:6361974

hm1

• Allelic Composition: Slco3a1^em1Smoc/Slco3a1^em1Smoc
• Genetic Background: C57BL/6J-Slco3a1^em1Smoc/Smoc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating alanine transaminase level ( J:279167 )

• mice fed 1% cholic acid to induce cholestasis exhibit increased alanine transaminse levels

• mice undergoing bile duct ligation to induce cholestatis exhibit higher levels of serum alanine transaminase 9 days, but not 3 days, after ligation

increased circulating aspartate transaminase level ( J:279167 )

• levels of aspartate transaminase are increased in 1% cholic acid-fed mice

• mice undergoing bile duct ligation to induce cholestatis exhibit higher levels of serum aspartate transaminase 9 days, but not 3 days, after ligation

• however, serum levels of alkaline phosphatase, direct bilirubin and total bilirubin levels are not different

abnormal bile salt homeostasis ( J:279167 )

• marker analysis indicates that 1% cholic acid-fed mice show a compromised hepatic adaptive response to cholestasis

• levels of hepatic 7-alpha-C4 are reduced in 1% cholic acid-fed mice

increased bile salt level ( J:279167 )

• bile acid level in the livers is greater than in wild-type mice after 1% cholic acid feeding

• conjugated bile acids taurocholic acid, taurodeoxycholate acid, and tauromuricholate acid in livers of 1% cholic acid-fed mice are increased by 1.51-, 9.04-, and 1.92-fold compared with controls

mortality/aging

decreased survivor rate ( J:279167 )

• 58% survival rate when mice are fed with 1% cholic acid