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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mir216aem2Uf
endonuclease-mediated mutation 2, University of Florida
MGI:6361472
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mir216aem2Uf/Mir216aem2Uf C57BL/6-Mir216aem2Uf MGI:6361647
cx2
 		Mir216aem2Uf/Mir216aem2Uf
Tg(Ela-KRAS*G12D)9Eps/0 		involves: C57BL/6N * FVB MGI:6361645


Genotype
MGI:6361647
hm1
Allelic
Composition		 Mir216aem2Uf/Mir216aem2Uf
Genetic
Background		 C57BL/6-Mir216aem2Uf
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir216aem2Uf mutation (0 available); any Mir216a mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
pancreatic acinar-to-ductal metaplasia ( J:278847 )
• in ductal cells cultured on collagen in the absence of growth factors
increased susceptibility to induced pancreatitis ( J:278847 )
• acute without complete regeneration leading to pancreatic ductal gland formation at day 4 following intraperitoneal injections of caerulein

immune system
increased susceptibility to induced pancreatitis ( J:278847 )
• acute without complete regeneration leading to pancreatic ductal gland formation at day 4 following intraperitoneal injections of caerulein




Genotype
MGI:6361645
cx2
Allelic
Composition		 Mir216aem2Uf/Mir216aem2Uf
Tg(Ela-KRAS*G12D)9Eps/0
Genetic
Background		 involves: C57BL/6N * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir216aem2Uf mutation (0 available); any Mir216a mutation (1 available)
Tg(Ela-KRAS*G12D)9Eps mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased pancreas tumor incidence ( J:278847 )
• as in Tg(Ela-KRAS*G12D)9Eps mice

endocrine/exocrine glands
increased pancreas tumor incidence ( J:278847 )
• as in Tg(Ela-KRAS*G12D)9Eps mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory