Phenotypes associated with this allele

• Allele Symbol: Sftpc^tm1.1Mfbs
• Allele Name: targeted mutation 1.1, Michael F Beers
• Allele ID: MGI:6360468
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sftpc^tm1.1Mfbs/Sftpc^tm1.1Mfbs	B6.Cg-Sftpc^tm1.1Mfbs	MGI:6740367
ht2	Sftpc^tm1.1Mfbs/Sftpc^+	B6.Cg-Sftpc^tm1.1Mfbs	MGI:6740368

Genotype
MGI:6740367

hm1

• Allelic Composition: Sftpc^tm1.1Mfbs/Sftpc^tm1.1Mfbs
• Genetic Background: B6.Cg-Sftpc^tm1.1Mfbs

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:267027 )

• no live progeny are obtained, however normal number of fetuses are obtained at E18.5

respiratory system

abnormal lung development ( J:267027 )

• lungs at E18.5 show arrested lung morphogenesis in late sacculation

abnormal lung saccule morphology ( J:267027 )

• E18.5 lungs show disrupted saccules containing poorly differentiated epithelium harboring ultrastructural changes

abnormal pulmonary alveolus epithelial cell morphology ( J:267027 )

• E18.5 lungs show a reduction in aquaporin 5, suggesting disruption of alveolar type II/ alveolar type I homeostasis

Genotype
MGI:6740368

ht2

• Allelic Composition: Sftpc^tm1.1Mfbs/Sftpc⁺
• Genetic Background: B6.Cg-Sftpc^tm1.1Mfbs

respiratory system

abnormal lung development ( J:267027 )

• lungs at E18.5 show arrested lung morphogenesis in late sacculation