Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh7em1Dsr mutation
(0 available);
any
Myh7 mutation
(95 available)
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mortality/aging
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• embryos die by E9.5 to E10 with evidence of heart failure
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cardiovascular system
Allelic Composition |
Myh7em1Dsr/Myh7+
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Genetic Background |
involves: C57BL/6J |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh7em1Dsr mutation
(0 available);
any
Myh7 mutation
(95 available)
|
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normal phenotype
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• no major phenotypic differences are seen compared to wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mrtfbem1Dsr mutation
(0 available);
any
Mrtfb mutation
(68 available)
Myh7em1Dsr mutation
(0 available);
any
Myh7 mutation
(95 available)
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cardiovascular system
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• mild hypertrabeculation and apical recesses in P3 ventricular wall
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muscle
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• mild hypertrabeculation and apical recesses in P3 ventricular wall
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mrtfbem1Dsr mutation
(0 available);
any
Mrtfb mutation
(68 available)
Myh7em1Dsr mutation
(0 available);
any
Myh7 mutation
(95 available)
Nkx2-5em1Dsr mutation
(0 available);
any
Nkx2-5 mutation
(21 available)
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cardiovascular system
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• mice exhibit deep trabeculations in the left ventricular wall at P3
• mice show a significant difference in trabecular complexity compared to controls
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• decrease in the apical wall thickness
• however, no changes in left ventricular free wall thickness
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• mice exhibit a reduction in cardiac function after transverse aortic constriction compared to wild-type mice, with incomplete penetrance
• however, cardiac function by echocardiography is normal at baseline in adult mice
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homeostasis/metabolism
muscle
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• mice exhibit deep trabeculations in the left ventricular wall at P3
• mice show a significant difference in trabecular complexity compared to controls
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