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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mir146btm1.1Lfl
targeted mutation 1.1, Li-Fan Lu
MGI:6359886
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Mir146btm1.1Lfl/Mir146btm1.1Lfl
Tg(Cd4-cre)1Cwi/0 		involves: C57BL/6 * DBA/2 MGI:6360067
cn2
 		Mir146tm1.1Lfl/Mir146tm1.1Lfl
Mir146btm1.1Lfl/Mir146btm1.1Lfl
Tg(Cd4-cre)1Cwi/0 		involves: C57BL/6 * DBA/2 MGI:6360068


Genotype
MGI:6360067
cn1
Allelic
Composition		 Mir146btm1.1Lfl/Mir146btm1.1Lfl
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir146btm1.1Lfl mutation (1 available); any Mir146b mutation (2 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:266124 )
N
• following immunization with sheep red blood cells, mice exhibit a wild-type response in elevation of germinal center B cells and T follicular helper cells




Genotype
MGI:6360068
cn2
Allelic
Composition		 Mir146tm1.1Lfl/Mir146tm1.1Lfl
Mir146btm1.1Lfl/Mir146btm1.1Lfl
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir146btm1.1Lfl mutation (1 available); any Mir146b mutation (2 available)
Mir146tm1.1Lfl mutation (1 available); any Mir146 mutation (9 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased germinal center B cell number ( J:266124 )
• in young unimmunized mice with a further increase in mice immunized with sheep red blood cells
increased T follicular helper cell number ( J:266124 )
• in young unimmunized mice with a further increase in mice immunized with sheep red blood cells
increased IgG level ( J:266124 )
• in mice immunized with sheep red blood cells

hematopoietic system
increased germinal center B cell number ( J:266124 )
• in young unimmunized mice with a further increase in mice immunized with sheep red blood cells
increased T follicular helper cell number ( J:266124 )
• in young unimmunized mice with a further increase in mice immunized with sheep red blood cells
increased IgG level ( J:266124 )
• in mice immunized with sheep red blood cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory