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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gk2em1Osb
endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
MGI:6359868
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gk2em1Osb/Gk2em1Osb involves: C57BL/6NJcl * DBA/2NJcl MGI:6359879
cx2
 		Gk2em1Osb/Gk2em1Osb
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0 		involves: C57BL/6NJcl * DBA/2NJcl MGI:6359880


Genotype
MGI:6359879
hm1
Allelic
Composition		 Gk2em1Osb/Gk2em1Osb
Genetic
Background		 involves: C57BL/6NJcl * DBA/2NJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gk2em1Osb mutation (2 available); any Gk2 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:278674 )
N
• female mice exhibit normal fertility
abnormal sperm mitochondrial sheath morphology ( J:278674 )
• fragmented prior to tail bending
• abnormal arrangement of crescent-like mitochondria
kinked sperm flagellum ( J:278674 )
• near the annulus
asthenozoospermia ( J:278674 )
• reduced average path, straight line, or curvilinear velocity before and after induction of capacitation
male infertility ( J:278674 )
• however, testes are normal
• viable and showed no overt abnormalities
impaired fertilization ( J:278674 )
• whether oocytes have intact or free cumulus
• however, fertilization of zona-free oocytes is normal

cellular
abnormal sperm mitochondrial sheath morphology ( J:278674 )
• fragmented prior to tail bending
• abnormal arrangement of crescent-like mitochondria
kinked sperm flagellum ( J:278674 )
• near the annulus
asthenozoospermia ( J:278674 )
• reduced average path, straight line, or curvilinear velocity before and after induction of capacitation




Genotype
MGI:6359880
cx2
Allelic
Composition		 Gk2em1Osb/Gk2em1Osb
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb/0
Genetic
Background		 involves: C57BL/6NJcl * DBA/2NJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gk2em1Osb mutation (2 available); any Gk2 mutation (20 available)
Tg(CAG-RFP,Acr-EGFP)RBGS002Osb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
impaired fertilization ( J:278674 )
• impaired passage of sperm through uterotubal junction




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory